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Lorlatinib Tablet

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Lorlatinib Tablet (brand name: Lorviqua) is a medication used to treat certain types of non-small cell lung cancer (NSCLC). It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs), and it works by targeting specific proteins involved in the growth and spread of cancer cells.

Key Information about Lorlatinib:

  1. Indication:
    • Lorlatinib is primarily used to treat advanced or metastatic non-small cell lung cancer (NSCLC) that has tested positive for anaplastic lymphoma kinase (ALK) gene rearrangements, or ROS1-positive NSCLC.
    • It is used in cases where the cancer has not responded to previous treatments, such as other ALK inhibitors or chemotherapy.
  2. Mechanism of Action:
    • Lorlatinib works by inhibiting the activity of abnormal proteins, particularly the ALK and ROS1 fusion proteins. These proteins are produced when parts of the ALK or ROS1 genes are rearranged in the cancer cells.
    • By blocking these proteins, Lorlatinib prevents the cancer cells from growing and dividing, thereby slowing down or stopping the progression of the cancer.
  3. Dosage:
    • The typical dosage of Lorlatinib is 100 mg once daily, taken orally with or without food.
    • The dosage may vary depending on individual patient needs, side effects, and treatment response.
  4. Common Side Effects:
    • Fatigue
    • Swelling (edema)
    • Weight gain
    • Diarrhea
    • Elevated cholesterol or triglycerides
    • Cognitive changes (such as memory problems)
  5. Serious Side Effects:
    • Severe lung problems, such as pneumonia
    • Heart problems (e.g., arrhythmias)
    • Severe allergic reactions
    • Liver problems
  6. Precautions:
    • Lorlatinib should not be used if there is a history of severe allergic reactions to the drug.
    • It can interact with other medications, so it’s important to inform your healthcare provider about all drugs, including over-the-counter medications and supplements.
    • Routine monitoring, including blood tests and lung function tests, may be needed during treatment.

Frequently Asked Questions (FAQs):

  1. Who is Lorlatinib used for?
    Lorlatinib is used for patients with ALK-positive or ROS1-positive NSCLC, particularly when other treatments have not worked.
  2. How is Lorlatinib taken?
    Lorlatinib is taken as a tablet, usually once a day. The dosage depends on the specific treatment plan prescribed by a doctor.
  3. What should I avoid while taking Lorlatinib?
    • Avoid grapefruit and grapefruit juice, as it can interfere with how the drug is processed in your body.
    • Let your healthcare provider know about any other prescription or over-the-counter medications you’re currently taking, particularly those that may impact liver function.
  4. Can Lorlatinib be used during pregnancy?
    Lorlatinib should not be used during pregnancy unless absolutely necessary. It is classified as a Category D drug, meaning it can harm the fetus.
  5. What are the potential side effects of Lorlatinib?
    Common side effects include fatigue, weight gain, and cognitive issues, while more severe side effects can involve lung problems, heart issues, and liver dysfunction.

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