Malegra DXT Plus is a medication commonly used to address two male sexual health issues simultaneously – erectile dysfunction (ED) and premature ejaculation (PE). It contains two active ingredients: sildenafil citrate, which is a phosphodiesterase type 5 (PDE5) inhibitor, and duloxetine, which is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI).